Nature Communications (Jan 2022)
Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae
- Anaïs Eskenazi,
- Cédric Lood,
- Julia Wubbolts,
- Maya Hites,
- Nana Balarjishvili,
- Lika Leshkasheli,
- Lia Askilashvili,
- Leila Kvachadze,
- Vera van Noort,
- Jeroen Wagemans,
- Marc Jayankura,
- Nina Chanishvili,
- Mark de Boer,
- Peter Nibbering,
- Mzia Kutateladze,
- Rob Lavigne,
- Maya Merabishvili,
- Jean-Paul Pirnay
Affiliations
- Anaïs Eskenazi
- Clinic of Infectious Diseases, CUB-Erasme Hospital
- Cédric Lood
- Department of Biosystems, Laboratory of Gene Technology, KU Leuven
- Julia Wubbolts
- Department of Infectious diseases, Leiden University Medical Centre
- Maya Hites
- Clinic of Infectious Diseases, CUB-Erasme Hospital
- Nana Balarjishvili
- Eliava Institute of Bacteriophages, Microbiology and Virology
- Lika Leshkasheli
- Eliava Institute of Bacteriophages, Microbiology and Virology
- Lia Askilashvili
- Eliava Institute of Bacteriophages, Microbiology and Virology
- Leila Kvachadze
- Eliava Institute of Bacteriophages, Microbiology and Virology
- Vera van Noort
- Department of microbial and molecular systems, Computational systems biology, KU Leuven
- Jeroen Wagemans
- Department of Biosystems, Laboratory of Gene Technology, KU Leuven
- Marc Jayankura
- Department of Orthopedic Surgery, CUB-Erasme Hospital
- Nina Chanishvili
- Eliava Institute of Bacteriophages, Microbiology and Virology
- Mark de Boer
- Department of Infectious diseases, Leiden University Medical Centre
- Peter Nibbering
- Department of Infectious diseases, Leiden University Medical Centre
- Mzia Kutateladze
- Eliava Institute of Bacteriophages, Microbiology and Virology
- Rob Lavigne
- Department of Biosystems, Laboratory of Gene Technology, KU Leuven
- Maya Merabishvili
- Laboratory for molecular and cellular technology, Queen Astrid Military Hospital
- Jean-Paul Pirnay
- Laboratory for molecular and cellular technology, Queen Astrid Military Hospital
- DOI
- https://doi.org/10.1038/s41467-021-27656-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
In this case study of a patient with fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term antibiotic therapy, the authors use a combination therapy of pre-adapted bacteriophage and antibiotics resulting in clinical, microbiological and radiological improvement.
