Survival outcomes of locally advanced gastric cancer cases with pathological complete response received neoadjuvant chemotherapy

Abstract

Abstract Objective The aim of this study is to explore the survival situation of locally advanced gastric cancer (GC) patients with pathological complete response (pCR) following neoadjuvant chemotherapy (NAC). Methods The clinical data of 13 patients with locally advanced GC who achieved a treated pCR with NAC following by surgical resection between January 2015 and December 2019 at Affiliated Cancer Hospital of Nanjing Medical University were analyzed retrospectively. Results Only 9.4% (13/138) can be classified as achieving pCR and these 13 cases of locally advanced GC patients are entered into the present study. The median follow‐up period of the survivors was 38 (range: 9‐68) months. As a whole, the overall survival (OS) rates at 1 and 3 years were 92% (95% confidence interval [CI] 78‐100) and 84% (95% CI 65‐100), and the RFS rates at 1 and 3 years were 85% (95% CI 66‐100) and 76% (95% CI 53‐98). Conclusions Although a pCR was a relatively rare event, locally advanced GC patients who achieved pCR with NAC have a good prognosis.

Keywords

• gastric cancer
• neoadjuvant chemotherapy
• pathological complete response