Matrix Proteins and Proteinases Network in Human Cardiovascular Diseases Explored By Cytoscape

Abstract

Matrix proteins and proteinases altered extracellular matrix that involves in various pathogenesis of cardiovascular diseases. Systematic review selected matrix metalloproteinase-7 (MMP7), a disintegrin and metalloproteinase-17 (ADAM17), type I collagen (COL1), syndecan (SDC), and versican (VCAN). Their network was drawn by Cytoscape and Agilent Literature Search. MMP7, ADAM17, and SDC were grouped together. VCAN and COL1 had inadequate evidence to connect their human potential networks that were more evidence in animal models. The findings may provide clues for further laboratory investigations.

Keywords

• Cytoscape
• matrix proteins
• metalloproteinase