TO THE QUESTION OF DIAGNOSTIC CRITERIA PERFECTION IN VIEW CIRCANNUAL VARIATION OF ORGANISM FUNCTIONING ADAPTIVE SYSTEMS IN CONDITIONS OF WESTERN SIBERIA

Abstract

Purpose of the research was studying circannual variation of parameters of hormonal regulation, lipids, oxidative systems of an organism of healthy men and women in conditions of Western Siberia.Monthly, within five years (2005–2009) on conditions of the voluntary informed consent 580 healthy donors (370 men and 210 women) in the age of from 25 up to 47 have been surveyed. In blood serum defined concentration of cortisol, insulin, thyroid hormones, concentration of cholesterol and other lipids, markers of stress and oxidative. Obtained data have been processed by adequate methods of the mathematical and statistical analysis.The analysis of results has shown that activity of functioning systems adaptation an of organism at all levels of the organization undergoes essential changes within a year. Revealed correlations are the certificate of cause and effect attitudes between the systems, providing adaptive mechanisms in constantly changing conditions of a living environment. The received results testify to an absolute must of revision of diagnostic criteria and expansions of concept of norm in view of circannual variation of functioning of physiological systems of an organism.

Keywords

• цирканнуальная динамика
• адаптация
• гормональная регуляция
• диагностические критерии