Cancers (Sep 2022)

Adequacy of Pain Treatment in Radiotherapy Departments: Results of a Multicenter Study on 2104 Patients (Arise)

  • Costanza M. Donati,
  • Elena Nardi,
  • Alice Zamagni,
  • Giambattista Siepe,
  • Filippo Mammini,
  • Francesco Cellini,
  • Alessia Di Rito,
  • Maurizio Portaluri,
  • Cristina De Tommaso,
  • Anna Santacaterina,
  • Consuelo Tamburella,
  • Rossella Di Franco,
  • Salvatore Parisi,
  • Sabrina Cossa,
  • Vincenzo Fusco,
  • Antonella Bianculli,
  • Pierpaolo Ziccarelli,
  • Luigi Ziccarelli,
  • Domenico Genovesi,
  • Luciana Caravatta,
  • Francesco Deodato,
  • Gabriella Macchia,
  • Francesco Fiorica,
  • Giuseppe Napoli,
  • Milly Buwenge,
  • Romina Rossi,
  • Marco Maltoni,
  • Alessio G. Morganti

DOI
https://doi.org/10.3390/cancers14194660
Journal volume & issue
Vol. 14, no. 19
p. 4660

Abstract

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Aim: The frequent inadequacy of pain management in cancer patients is well known. Moreover, the quality of analgesic treatment in patients treated with radiotherapy (RT) has only been rarely assessed. In order to study the latter topic, we conducted a multicenter, observational and prospective study based on the Pain Management Index (PMI) in RT Italian departments. Methods: We collected data on age, gender, tumor site and stage, performance status, treatment aim, and pain (type: CP—cancer pain, NCP—non-cancer pain, MP—mixed pain; intensity: NRS: Numeric Rating Scale). Furthermore, we analyzed the impact on PMI on these parameters, and we defined a pain score with values from 0 (NRS: 0, no pain) to 3 (NRS: 7–10: intense pain) and an analgesic score from 0 (pain medication not taken) to 3 (strong opioids). By subtracting the pain score from the analgesic score, we obtained the PMI value, considering cases with values < 0 as inadequate analgesic prescriptions. The Ethics Committees of the participating centers approved the study (ARISE-1 study). Results: Two thousand one hundred four non-selected outpatients with cancer and aged 18 years or older were enrolled in 13 RT departments. RT had curative and palliative intent in 62.4% and 37.6% patients, respectively. Tumor stage was non-metastatic in 57.3% and metastatic in 42.7% of subjects, respectively. Pain affected 1417 patients (CP: 49.5%, NCP: 32.0%; MP: 18.5%). PMI was < 0 in 45.0% of patients with pain. At multivariable analysis, inadequate pain management was significantly correlated with curative RT aim, ECOG performance status = 1 (versus both ECOG-PS3 and ECOG- PS4), breast cancer, non-cancer pain, and Central and South Italy RT Departments (versus Northern Italy).Conclusions: Pain management was less adequate in patients with more favorable clinical condition and stage. Educational and organizational strategies are needed in RT departments to reduce the non-negligible percentage of patients with inadequate analgesic therapy.

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