The essential and critical role of laboratory medicine in the current Coronavirus disease of 2019 (COVID19) outbreak regarding diagnosis, therapeutics and prognostics cannot be overruled. No laboratory test is perfect and there is always a dilemma especially for respiratory diseases as in case of tuberculosis. Sensitivity, specificity, PPV and NPV are not always perfect for any one test. In case of COVID-19, we need to step ahead of PCR and also start supplementary serology testing. It will provide wide range of information, important for future thinking, planning and actions against COVID-19.