Nature Communications (May 2021)

A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

  • Louciné Mitoyan,
  • Véronique Chevrier,
  • Hector Hernandez-Vargas,
  • Alexane Ollivier,
  • Zeinab Homayed,
  • Julie Pannequin,
  • Flora Poizat,
  • Cécile De Biasi-Cador,
  • Emmanuelle Charafe-Jauffret,
  • Christophe Ginestier,
  • Géraldine Guasch

DOI
https://doi.org/10.1038/s41467-021-23034-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute to squamous and glandular epithelia during homeostasis and repair.