Assessment of Clinical Profile and Treatment Outcome in Vaccinated and Unvaccinated SARS-CoV-2 Infected Patients
Ganesh Korishettar,
Prashanth Chikkahonnaiah,
SubbaRao V. Tulimilli,
Siva Dallavalasa,
Shashidhar H. Byrappa,
SubbaRao V. Madhunapantula,
Ravindra P. Veeranna
Affiliations
Ganesh Korishettar
Department of Pulmonary Medicine, Mysore Medical College and Research Institute (MMC&RI), Mysuru 570001, Karnataka, India
Prashanth Chikkahonnaiah
Department of Pulmonary Medicine, Mysore Medical College and Research Institute (MMC&RI), Mysuru 570001, Karnataka, India
SubbaRao V. Tulimilli
Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST Supported Center), Department of Biochemistry (DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research (JSS AHER), Mysuru 570004, Karnataka, India
Siva Dallavalasa
Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST Supported Center), Department of Biochemistry (DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research (JSS AHER), Mysuru 570004, Karnataka, India
Shashidhar H. Byrappa
Department of Biochemistry, Council of Scientific and Industrial Research (CSIR)—Central Food Technological Research Institute (CFTRI), Mysuru 570020, Karnataka, India
SubbaRao V. Madhunapantula
Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST Supported Center), Department of Biochemistry (DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research (JSS AHER), Mysuru 570004, Karnataka, India
Ravindra P. Veeranna
Department of Pathology, Mysore Medical College and Research Institute (MMC&RI), Mysuru 570001, Karnataka, India
Vaccines against severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) infection, which causes coronavirus disease–19 (COVID-19) in humans, have been developed and are being tested for safety and efficacy. We conducted the cross-sectional prospective cohort study on 820 patients who were positive for SARS-CoV-2 and were admitted to Princess Krishnajammanni trauma care centre (PKTCC), Mysore, which was converted to a designated COVID hospital between April 2021 to July 2021. After obtaining the informed consent, RT-PCR report, vaccination certificate and patient history, patients were classified according to their vaccination status. Results from the study showed decreases in serum ferritin levels, clinical symptoms, improvement in oxygen saturation, early recovery in patients having diabetes and hypertension, and a substantial reduction in the overall duration of hospital stay in vaccinated patients compared to unvaccinated patients. Further, fully vaccinated patients showed better outcomes compared to single dose vaccinated and nonvaccinated patients. Taken together, our findings reaffirm the vaccine’s effectiveness in reducing case fatality and promoting faster recovery compared to nonvaccinated patients. Efforts to increase the number of immunized subjects in the community help to achieve herd immunity and offer protection against the severity of COVID-19 and associated complications while minimizing the public health and economic burden.
