CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

Magdalena B. Rother; Stefania Pellegrino; Rebecca Smith; Marco Gatti; Cornelia Meisenberg; Wouter W. Wiegant; Martijn S. Luijsterburg; Ralph Imhof; Jessica A. Downs; Alfred C. O. Vertegaal; Sébastien Huet; Matthias Altmeyer; Haico van Attikum

doi:10.1038/s41467-020-19502-5

Nature Communications (Nov 2020)

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

Magdalena B. Rother,
Stefania Pellegrino,
Rebecca Smith,
Marco Gatti,
Cornelia Meisenberg,
Wouter W. Wiegant,
Martijn S. Luijsterburg,
Ralph Imhof,
Jessica A. Downs,
Alfred C. O. Vertegaal,
Sébastien Huet,
Matthias Altmeyer,
Haico van Attikum

Affiliations

Magdalena B. Rother: Department of Human Genetics, Leiden University Medical Center
Stefania Pellegrino: Department of Molecular Mechanisms of Disease, University of Zurich
Rebecca Smith: Univ Rennes, CNRS, IGDR (Institut de génétique et développement de Rennes)—UMR 6290
Marco Gatti: Department of Molecular Mechanisms of Disease, University of Zurich
Cornelia Meisenberg: The Institute of Cancer Research, Royal Cancer Hospital
Wouter W. Wiegant: Department of Human Genetics, Leiden University Medical Center
Martijn S. Luijsterburg: Department of Human Genetics, Leiden University Medical Center
Ralph Imhof: Department of Molecular Mechanisms of Disease, University of Zurich
Jessica A. Downs: The Institute of Cancer Research, Royal Cancer Hospital
Alfred C. O. Vertegaal: Department of Cell and Chemical Biology, Leiden University Medical Center
Sébastien Huet: Univ Rennes, CNRS, IGDR (Institut de génétique et développement de Rennes)—UMR 6290
Matthias Altmeyer: Department of Molecular Mechanisms of Disease, University of Zurich
Haico van Attikum: Department of Human Genetics, Leiden University Medical Center

DOI: https://doi.org/10.1038/s41467-020-19502-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 19

Abstract

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Chromatin is dynamically remodeled in response to DNA damage in favour of repair. Here the authors reveal how the chromatin remodeler CHD7 and chromatin binding protein 53BP1 regulate distinct DNA repair pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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