Emergence of rifampicin-resistant staphylococci on the skin and nose of rifampicin-treated patients with an orthopaedic-device-related infection

A. Wallimann; A. Wallimann; Y. Achermann; Y. Achermann; Y. Achermann; C. Ferris; M. Morgenstern; M. Morgenstern; M. Clauss; M. Clauss; V. Stadelmann; H. A. Rüdiger; L. O'Mahony; T. F. Moriarty; T. F. Moriarty

doi:10.5194/jbji-9-191-2024

Journal of Bone and Joint Infection (Jul 2024)

Emergence of rifampicin-resistant staphylococci on the skin and nose of rifampicin-treated patients with an orthopaedic-device-related infection

A. Wallimann,
A. Wallimann,
Y. Achermann,
Y. Achermann,
Y. Achermann,
C. Ferris,
M. Morgenstern,
M. Morgenstern,
M. Clauss,
M. Clauss,
V. Stadelmann,
H. A. Rüdiger,
L. O'Mahony,
T. F. Moriarty,
T. F. Moriarty

Affiliations

A. Wallimann: AO Research Institute Davos, Davos, Switzerland
A. Wallimann: Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Y. Achermann: Department of Internal Medicine, Hospital Zollikerberg, Zollikerberg, Switzerland
Y. Achermann: Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Y. Achermann: Department of Infectious Diseases and Hospital Epidemiology, University of Zurich, Zurich, Switzerland
C. Ferris: AO Research Institute Davos, Davos, Switzerland
M. Morgenstern: Center for Musculoskeletal Infections (ZMSI), University Hospital Basel, Basel, Switzerland
M. Morgenstern: Department of Orthopedic and Trauma Surgery, University Hospital Basel, Basel, Switzerland
M. Clauss: Center for Musculoskeletal Infections (ZMSI), University Hospital Basel, Basel, Switzerland
M. Clauss: Department of Orthopedic and Trauma Surgery, University Hospital Basel, Basel, Switzerland
V. Stadelmann: Department of Research and Development, Schulthess Klinik, Zurich, Switzerland
H. A. Rüdiger: Department of Hip and Knee Surgery, Schulthess Klinik, Zurich, Switzerland
L. O'Mahony: Departments of Medicine and Microbiology, APC Microbiome Ireland, University College Cork, College Road, Cork, Ireland
T. F. Moriarty: AO Research Institute Davos, Davos, Switzerland
T. F. Moriarty: Center for Musculoskeletal Infections (ZMSI), University Hospital Basel, Basel, Switzerland

DOI: https://doi.org/10.5194/jbji-9-191-2024
Journal volume & issue: Vol. 9
pp. 191 – 196

Abstract

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Rifampicin is a key antibiotic in the treatment of staphylococcal biofilm infections. In this pilot study, we found that patients who received rifampicin for treatment of an orthopaedic-device-related infection (ODRI) were colonized with rifampicin-resistant staphylococci during treatment and this persisted for up to 2 months after cessation of treatment.

Published in Journal of Bone and Joint Infection

ISSN: 2206-3552 (Online)
Publisher: Copernicus Publications
Country of publisher: Germany
LCC subjects: Medicine: Surgery: Orthopedic surgery
Website: https://www.journal-of-bone-and-joint-infection.net/

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