Synthesis, characterization and In-vitro studies of CNT/Gd2O3 hybrid structure
Rima Paul,
Dipanwita Chatterjee,
Lopamudra Das Ghosh,
Venkatesha Narayanswamy,
Mahander Pratap Singh,
Manish Agarwal,
Deepshikha Ghosh,
Mithun Radhakrishna,
Chandra Sekhar Tiwary,
Ivo Provazník,
Kamanio Chattopadhyay
Affiliations
Rima Paul
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India; Department of Biomedical Engineering, Brno University of Technology, Brno 61600, Czech Republic; Corresponding author.
Dipanwita Chatterjee
Materials Research Centre, Indian Institute of Science, Bangalore 560012, India
Lopamudra Das Ghosh
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India; Department of Biomedical Engineering, Texas A& M University, Texas 77843, USA
Venkatesha Narayanswamy
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India
Mahander Pratap Singh
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India
Manish Agarwal
Computer Services Centre, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India
Deepshikha Ghosh
Department of Chemical Engineering, Indian Institute of Technology Gandhinagar, Gujarat 382355, India
Mithun Radhakrishna
Department of Chemical Engineering, Indian Institute of Technology Gandhinagar, Gujarat 382355, India
Chandra Sekhar Tiwary
Metallurgical and Materials Engineering, Indian Institute of Technology Kharagpur, West Bengal 721302, India; Department of Material Science and Nano Engineering, Rice University, Houston, Texas 77005, USA
Ivo Provazník
Department of Biomedical Engineering, Brno University of Technology, Brno 61600, Czech Republic
Kamanio Chattopadhyay
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India
Carbon nanotubes have been explored in various fields of science and technology due to their unique properties. However, their toxic nature put limitations to its consideration for the bio-medical applications. In our work, we report the synthesis of paramagnetic CNT/Gd2O3 hybrid nanostructures through easily scalable electrochemical deposition technique. The nanostructure has shown significant longitudinal relaxivity of 18.93 mM−1s−1 for water protons indicating its possibility to be used as an MRI contrast agent. The in-vitro cytotoxicity test on the normal (HaCaT) and cancerous (HeLa) cells reveal that CNT/Gd2O3 hybrid nanostructure is bio-compatible in comparison to the pure CNTs, which is further supported by our theoretical studies using MD simulations.
