ASEAN Journal on Science and Technology for Development (Nov 2017)

APPLICATION OF NMR IN THE INVESTIGATION OF DYNAMIC TAUTOMERISM OF 4(3H)-QUINAZOLINONE SYSTEM

  • Pham Thi Thanh My,
  • Chu Dinh Kinh,
  • Thanh Thi Thu Thuy,
  • Nguyen Ngoc Vinh,
  • Nguyen Thi Phuong Chi

DOI
https://doi.org/10.29037/ajstd.275
Journal volume & issue
Vol. 25, no. 2
pp. 445 – 455

Abstract

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Tautomerism of 4(3H)-quinazolinone system with [(2-hydroxyphenyl)methylene]-2-(4oxoquinazolin-3(4H)-yl)acetohydrazide and N’-[(1E)-(4-hydroxy-3-methoxyphenyl)methylene]-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide as two representative compounds was investigated on the basis of 1H NMR method at coalescence with the help of line formprogramme. The dynamic parameters such as k, Ea, DG*, DH*, DS* were fully calculated with high reliability.