G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis

Annemarie Boleij; Payam Fathi; William Dalton; Ben Park; Xinqun Wu; David Huso; Jawara Allen; Sepideh Besharati; Robert A. Anders; Franck Housseau; Amanda E. Mackenzie; Laura Jenkins; Graeme. Milligan; Shaoguang Wu; Cynthia L. Sears

doi:10.1038/s42003-021-02014-3

Communications Biology (May 2021)

G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis

Annemarie Boleij,
Payam Fathi,
William Dalton,
Ben Park,
Xinqun Wu,
David Huso,
Jawara Allen,
Sepideh Besharati,
Robert A. Anders,
Franck Housseau,
Amanda E. Mackenzie,
Laura Jenkins,
Graeme. Milligan,
Shaoguang Wu,
Cynthia L. Sears

Affiliations

Annemarie Boleij: Johns Hopkins University, Department of Medicine, Division of Infectious Diseases
Payam Fathi: Johns Hopkins University, Department of Medicine, Division of Infectious Diseases
William Dalton: Johns Hopkins University, Department of Oncology Center-Hematologic Malignancies
Ben Park: Johns Hopkins University, Department of Oncology Center-Hematologic Malignancies
Xinqun Wu: Johns Hopkins University, Department of Medicine, Division of Infectious Diseases
David Huso: Johns Hopkins University, Department of Molecular and Comparative Pathobiology
Jawara Allen: Johns Hopkins University, Department of Medicine, Division of Infectious Diseases
Sepideh Besharati: Johns Hopkins University, Department of Pathobiology
Robert A. Anders: Johns Hopkins University, Department of Pathobiology
Franck Housseau: Johns Hopkins University, Department of Oncology Sidney Kimmel Comprehensive Cancer Center
Amanda E. Mackenzie: Centre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow
Laura Jenkins: Centre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow
Graeme. Milligan: Centre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow
Shaoguang Wu: Johns Hopkins University, Department of Medicine, Division of Infectious Diseases
Cynthia L. Sears: Johns Hopkins University, Department of Medicine, Division of Infectious Diseases

DOI: https://doi.org/10.1038/s42003-021-02014-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Boleij et al. show that G protein-coupled receptor 35 (GPR35) regulates the responses to enterotoxigenic Bacteroides fragilis (ETBF) in colonic epithelial cells. They find that GPR35-deficiency nearly protected mice from ETBF-induced death, suggesting the importance of GPR35 in sensing ETBF in the colon.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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