Computer Simulation of Cardiomyocyte Membrane Exposure to First<Phase Bipolar Defibrillation Impulses

Abstract

Objective: to evaluate the effects of the immunostimulants panavir and derinate on a postresuscitation process in animals of different sexes.Material and methods. The investigation was made on 200—250-g albino rats of both sexes in winter. Circulation was stopped by intrathoracic ligation of the cardiac vascular bundle in ether<anesthetized rats for 10 min. Functional recovery of the central nervous system and changes in sex steroid hormones were assessed in the postresuscitation period. The investigation used two immunoactive drugs: panavir 0.02 mg/kg and derinate 150 μg/kg. Either agent was intramuscularly injected twice: at 3 0 minutes after resuscitation and on the following day.Results. The injected drugs were ascertained to have a positive effect on functional recovery of the brain. Their use was shown to modify the sex steroid hormone profiles in both males and females in the early postresuscitation period.Conclusion. The findings suggest that the immunoactive agents are able to affect the nervous and endocrine systems in critical conditions.

Keywords

• ischemia, central nervous system, immunoactive drugs, steroid hormones, sex differences