Relationship between carbon monoxide poisoning, lactate and cardiac marker

Abstract

INTRODUCTION: Carbon monoxide reduces blood oxygen transport capacity and causes tissue hypoxia by binding to hemoglobin. We aimed to evaluate the relationship between Troponin I, a myocardial injury marker, Lactate, a tissue hypoxia marker and Carboxyhemoglobin levels in patients presenting with CO poisoning. METHODS: Patients with a carboxyhemoglobin level of more than 15% who applied to our clinic between 01.01.2015 and 01.01.2017 were retrospectively screened from the hospital computerized patient information management system. The demographic characteristics of the patients, the season they applied, hemoglobin, leukocyte, platelet, mean platelet volume, pH, carboxyhemoglobin, lactate, troponin I levels and their relationships were evaluated. RESULTS: 135 patients were included in our study. Female gender was predominant (59.4%, n=82). It was seen that 65.9% of the patients (n = 91) applied in winter. In our study, it was found that there was statistically significant weak linear relationship between age and Troponin I levels (r=0.269, p=0.008). Besides, there was very weak positive relationship between Carboxyhemoglobin and Troponin I levels (r=0.239, p=0.019) and weak positive relationship between Carboxyhemoglobin and Lactate values (r=0.361, p<0.001). DISCUSSION AND CONCLUSION: Although our study showed that Troponin I and Lactate levels were associatend with the degree of intoxication, the value of the evidence should be established with comprehensive studies in this area.

Keywords

• carboxyhemoglobin
• carbon monoxide
• lactate
• troponin