mSystems (Jun 2021)

The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle

  • Timothy R. Howard,
  • Marni S. Crow,
  • Todd M. Greco,
  • Krystal K. Lum,
  • Tuo Li,
  • Ileana M. Cristea

DOI
https://doi.org/10.1128/mSystems.00397-21
Journal volume & issue
Vol. 6, no. 3

Abstract

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Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression.