The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle
Timothy R. Howard,
Marni S. Crow,
Todd M. Greco,
Krystal K. Lum,
Tuo Li,
Ileana M. Cristea
Affiliations
Timothy R. Howard
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
Marni S. Crow
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
Todd M. Greco
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
Krystal K. Lum
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
Tuo Li
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression.
