Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in oral lichen planus patients with or without microcytosis

Yi-Pang Lee; Ying-Tai Jin; Julia Yu-Fong Chang; Yi-Ping Wang; Andy Sun; Chun-Pin Chiang

Journal of Dental Sciences (Jul 2025)

Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in oral lichen planus patients with or without microcytosis

Yi-Pang Lee,
Ying-Tai Jin,
Julia Yu-Fong Chang,
Yi-Ping Wang,
Andy Sun,
Chun-Pin Chiang

Affiliations

Yi-Pang Lee: Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien, Taiwan
Ying-Tai Jin: Department of Pathology, Taiwan Adventist Hospital, Taipei, Taiwan; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Julia Yu-Fong Chang: Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan
Yi-Ping Wang: Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan
Andy Sun: Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Dentistry, National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10048, Taiwan.
Chun-Pin Chiang: Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan.

Journal volume & issue: Vol. 20, no. 3
pp. 1877 – 1884

Abstract

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Background/purpose: Microcytosis is defined as having mean corpuscular volume (MCV) < 80 fL. This study evaluated whether 78 oral lichen planus (OLP) patients with microcytosis (microcytosis/OLP patients) and 510 OLP patients without microcytosis (non-microcytosis/OLP patients) had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects. Materials and methods: Complete blood count and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 78 microcytosis/OLP patients, 510 non-microcytosis/OLP patients, and 588 healthy control subjects were measured and compared. Results: We found that 71.8 %, 46.2 %, 10.3 %, 0.0 %, 18.0 %, and 20.5 % of 78 microcytosis/OLP patients and 18.0 %, 12.4 %, 10.2 %, 1.4 %, 21.6 %, and 24.1 % of 510 non-microcytosis/OLP patients had blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Both 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects (all P-values <0.001). Moreover, 78 microcytosis/OLP patients had significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients. Conclusion: We conclude that our 78 microcytosis/OLP patients and 510 non-microcytosis/OLP patients have significantly higher frequencies of anemia, serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects. Moreover, 78 microcytosis/OLP patients also have significantly higher frequencies of blood hemoglobin and serum iron deficiencies than 510 non-microcytosis/OLP patients.

Published in Journal of Dental Sciences

ISSN: 1991-7902 (Print)
Publisher: Elsevier
Country of publisher: Taiwan, Province of China
LCC subjects: Medicine: Dentistry
Website: http://www.journals.elsevier.com/journal-of-dental-sciences/

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