Frontiers in Molecular Neuroscience (Jun 2020)
Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice
- Dong Zhang,
- Dong Zhang,
- Dong Zhang,
- Dong Zhang,
- Dong Zhang,
- Hongchao Men,
- Hongchao Men,
- Hongchao Men,
- Hongchao Men,
- Hongchao Men,
- Ludi Zhang,
- Ludi Zhang,
- Ludi Zhang,
- Ludi Zhang,
- Xiangxin Gao,
- Xiangxin Gao,
- Xiangxin Gao,
- Xiangxin Gao,
- Jingjing Wang,
- Jingjing Wang,
- Jingjing Wang,
- Jingjing Wang,
- Leying Li,
- Leying Li,
- Leying Li,
- Leying Li,
- Qiaoying Zhu,
- Qiaoying Zhu,
- Qiaoying Zhu,
- Qiaoying Zhu,
- Hailin Zhang,
- Hailin Zhang,
- Hailin Zhang,
- Hailin Zhang,
- Zhanfeng Jia,
- Zhanfeng Jia,
- Zhanfeng Jia,
- Zhanfeng Jia
Affiliations
- Dong Zhang
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Dong Zhang
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Dong Zhang
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Dong Zhang
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Dong Zhang
- Department of Anesthesiology, Hebei General Hospital, Shijiazhuang, China
- Hongchao Men
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Hongchao Men
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Hongchao Men
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Hongchao Men
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Hongchao Men
- Department of Anesthesiology, Hebei General Hospital, Shijiazhuang, China
- Ludi Zhang
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Ludi Zhang
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Ludi Zhang
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Ludi Zhang
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Xiangxin Gao
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Xiangxin Gao
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Xiangxin Gao
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Xiangxin Gao
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Jingjing Wang
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Jingjing Wang
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Jingjing Wang
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Jingjing Wang
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Leying Li
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Leying Li
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Leying Li
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Leying Li
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Qiaoying Zhu
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Qiaoying Zhu
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Qiaoying Zhu
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Qiaoying Zhu
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Hailin Zhang
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Hailin Zhang
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Hailin Zhang
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Hailin Zhang
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- Zhanfeng Jia
- Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
- Zhanfeng Jia
- Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University, Shijiazhuang, China
- Zhanfeng Jia
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China
- Zhanfeng Jia
- The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China
- DOI
- https://doi.org/10.3389/fnmol.2020.00105
- Journal volume & issue
-
Vol. 13
Abstract
M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/Kv7 channel activity contributes to generation of itch in mice. CQ enhances excitability of the primary sensory neurons through inhibiting M/Kv7 potassium currents in a Ca2+ influx-dependent manner. Specific M/Kv7 channel opener retigabine (RTG) or tannic acid (TA) not only reverses the CQ-induced enhancement of neuronal excitability but also suppresses the CQ-induced itch behavior. Systemic application of RTG or TA also significantly inhibits the itch behavior induced by a variety of pruritogens. Taken together, our findings provide novel insight into the molecular basis of CQ-induced itch sensation in mammals that can be applied to the development of strategies to mitigate itch behavior.
Keywords
