Heart Failure With Mid-range Ejection Fraction: Every Coin Has Two Sides

Kaiyuan Zhu; Teng Ma; Yang Su; Xin Pan; Rongrong Huang; Fenglei Zhang; Chunxi Yan; Dachun Xu; Dachun Xu

doi:10.3389/fcvm.2021.683418

Frontiers in Cardiovascular Medicine (Jul 2021)

Heart Failure With Mid-range Ejection Fraction: Every Coin Has Two Sides

Kaiyuan Zhu,
Teng Ma,
Yang Su,
Xin Pan,
Rongrong Huang,
Fenglei Zhang,
Chunxi Yan,
Dachun Xu,
Dachun Xu

Affiliations

Kaiyuan Zhu: Department of Cardiology, Qidong People's Hospital, Nantong, China
Teng Ma: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
Yang Su: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
Xin Pan: Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
Rongrong Huang: Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
Fenglei Zhang: Department of Cardiology, Qidong People's Hospital, Nantong, China
Chunxi Yan: Department of Cardiology, Qidong People's Hospital, Nantong, China
Dachun Xu: Department of Cardiology, Qidong People's Hospital, Nantong, China
Dachun Xu: Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fcvm.2021.683418
Journal volume & issue: Vol. 8

Abstract

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This review summarizes current knowledge regarding clinical epidemiology, pathophysiology, and prognosis for patients with HFmrEF in comparison to HFrEF and HFpEF. Although recommended treatments currently focus on aggressive management of comorbidities, we summarize potentially beneficial therapies that can delay the process of heart failure by blocking the pathophysiology mechanism. More studies are needed to further characterize HFmrEF and identify effective management strategies that can reduce cardiovascular morbidity and mortality of patients with HFmrEF.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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