CLINICAL SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN NON-ST-SEGMENT-ELEVATION ACUTE CORONARY SYNDROME IN SUBJECTS UNDER 55 YEARS OF AGE

Abstract

The role and clinical significance of endothelial dysfunction (ED) in the diagnostics and prognosis of non-ST-segment-elevation acute coronary syndrome (ACS) in subjects under 55 years of age with verified CHD (by heart catheterization). The comparison group was made of 32 patients with stable angina (SA) II and III functional classes. Non-Q-wave myocardial infarction was diagnosed in 50 (37 %) troponin-positive patients, unstable angina in 84 (63 %) troponin-positive patients. Endothelial function was evaluated by plasma and red blood cells nitrates and I-arginine levels, the number of desquamated endotheliocytes (DE) in plasma, concealed endothelial dysfunction was revealed. A reliable increase of nitrates and DE has been found, most marked in patients with ACS. ED may be present as concealed (compensated), intermediate (subcompensated) and acute (decompensated) forms.

Keywords

• single-time study
• endothelial dysfunction
• non-st-segment-elevation acute coronary syndrome
• young and medium age