Nature Communications (Jan 2022)

Maximizing response to intratumoral immunotherapy in mice by tuning local retention

  • Noor Momin,
  • Joseph R. Palmeri,
  • Emi A. Lutz,
  • Noor Jailkhani,
  • Howard Mak,
  • Anthony Tabet,
  • Magnolia M. Chinn,
  • Byong H. Kang,
  • Virginia Spanoudaki,
  • Richard O. Hynes,
  • K. Dane Wittrup

DOI
https://doi.org/10.1038/s41467-021-27390-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Understanding the pharmacokinetics of locally-injected drugs could aid in the design of immunotherapies to maximize their therapeutic effect. Here, by evaluating different IL-2 fusion proteins, the authors show that molecular weight and matrix binding affect anti-tumor immune response and report a pharmacokinetic framework to predict response to intratumoral IL-2 therapy.