Skin T cells maintain their diversity and functionality in the elderly

Hanako Koguchi-Yoshioka; Elena Hoffer; Stanley Cheuk; Yutaka Matsumura; Sa Vo; Petra Kjellman; Lucian Grema; Yosuke Ishitsuka; Yoshiyuki Nakamura; Naoko Okiyama; Yasuhiro Fujisawa; Manabu Fujimoto; Liv Eidsmo; Rachael A. Clark; Rei Watanabe

doi:10.1038/s42003-020-01551-7

Communications Biology (Jan 2021)

Skin T cells maintain their diversity and functionality in the elderly

Hanako Koguchi-Yoshioka,
Elena Hoffer,
Stanley Cheuk,
Yutaka Matsumura,
Sa Vo,
Petra Kjellman,
Lucian Grema,
Yosuke Ishitsuka,
Yoshiyuki Nakamura,
Naoko Okiyama,
Yasuhiro Fujisawa,
Manabu Fujimoto,
Liv Eidsmo,
Rachael A. Clark,
Rei Watanabe

Affiliations

Hanako Koguchi-Yoshioka: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Elena Hoffer: Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet
Stanley Cheuk: Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet
Yutaka Matsumura: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Sa Vo: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Petra Kjellman: Diagnostiskt Centrum Hud
Lucian Grema: Diagnostiskt Centrum Hud
Yosuke Ishitsuka: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Yoshiyuki Nakamura: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Naoko Okiyama: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Yasuhiro Fujisawa: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Manabu Fujimoto: Department of Dermatology, Faculty of Medicine, University of Tsukuba
Liv Eidsmo: Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet
Rachael A. Clark: Department of Dermatology, Brigham and Women’s Hospital
Rei Watanabe: Department of Dermatology, Faculty of Medicine, University of Tsukuba

DOI: https://doi.org/10.1038/s42003-020-01551-7
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 8

Abstract

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Koguchi-Yoshioka et al. demonstrate that functional activities and diversity of T cells are highly maintained in the skin of elderly people when compared with those in the blood regardless of the ethnicity of the participants or the experimental procedures. They also find the accumulation of epidermal T cells with maintained cytokine production in the elderly participants.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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