A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

Tanzeela Arshad; Fizzah Mansur; Richard Palek; Richard Palek; Sobia Manzoor; Sobia Manzoor; Vaclav Liska; Vaclav Liska

doi:10.3389/fimmu.2020.02148

Frontiers in Immunology (Sep 2020)

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

Tanzeela Arshad,
Fizzah Mansur,
Richard Palek,
Richard Palek,
Sobia Manzoor,
Sobia Manzoor,
Vaclav Liska,
Vaclav Liska

Affiliations

Tanzeela Arshad: Molecular Virology and Immunology Research Group, Atta-ur-Rahman School of Applied Bio-Sciences, National University of Sciences and Technology, Islamabad, Pakistan
Fizzah Mansur: Molecular Virology and Immunology Research Group, Atta-ur-Rahman School of Applied Bio-Sciences, National University of Sciences and Technology, Islamabad, Pakistan
Richard Palek: Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia
Richard Palek: Laboratory of Cancer Treatment and Tissue Regeneration, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
Sobia Manzoor: Molecular Virology and Immunology Research Group, Atta-ur-Rahman School of Applied Bio-Sciences, National University of Sciences and Technology, Islamabad, Pakistan
Sobia Manzoor: Laboratory of Cancer Treatment and Tissue Regeneration, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
Vaclav Liska: Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia
Vaclav Liska: Laboratory of Cancer Treatment and Tissue Regeneration, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia

DOI: https://doi.org/10.3389/fimmu.2020.02148
Journal volume & issue: Vol. 11

Abstract

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Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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