Nature Communications (Aug 2018)
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
- Xuemei Ji,
- Yohan Bossé,
- Maria Teresa Landi,
- Jiang Gui,
- Xiangjun Xiao,
- David Qian,
- Philippe Joubert,
- Maxime Lamontagne,
- Yafang Li,
- Ivan Gorlov,
- Mariella de Biasi,
- Younghun Han,
- Olga Gorlova,
- Rayjean J. Hung,
- Xifeng Wu,
- James McKay,
- Xuchen Zong,
- Robert Carreras-Torres,
- David C. Christiani,
- Neil Caporaso,
- Mattias Johansson,
- Geoffrey Liu,
- Stig E. Bojesen,
- Loic Le Marchand,
- Demetrios Albanes,
- Heike Bickeböller,
- Melinda C. Aldrich,
- William S. Bush,
- Adonina Tardon,
- Gad Rennert,
- Chu Chen,
- M. Dawn Teare,
- John K. Field,
- Lambertus A. Kiemeney,
- Philip Lazarus,
- Aage Haugen,
- Stephen Lam,
- Matthew B. Schabath,
- Angeline S. Andrew,
- Hongbing Shen,
- Yun-Chul Hong,
- Jian-Min Yuan,
- Pier A. Bertazzi,
- Angela C. Pesatori,
- Yuanqing Ye,
- Nancy Diao,
- Li Su,
- Ruyang Zhang,
- Yonathan Brhane,
- Natasha Leighl,
- Jakob S. Johansen,
- Anders Mellemgaard,
- Walid Saliba,
- Christopher Haiman,
- Lynne Wilkens,
- Ana Fernandez-Somoano,
- Guillermo Fernandez-Tardon,
- Erik H. F. M. van der Heijden,
- Jin Hee Kim,
- Juncheng Dai,
- Zhibin Hu,
- Michael P. A. Davies,
- Michael W. Marcus,
- Hans Brunnström,
- Jonas Manjer,
- Olle Melander,
- David C. Muller,
- Kim Overvad,
- Antonia Trichopoulou,
- Rosario Tumino,
- Jennifer Doherty,
- Gary E. Goodman,
- Angela Cox,
- Fiona Taylor,
- Penella Woll,
- Irene Brüske,
- Judith Manz,
- Thomas Muley,
- Angela Risch,
- Albert Rosenberger,
- Kjell Grankvist,
- Mikael Johansson,
- Frances Shepherd,
- Ming-Sound Tsao,
- Susanne M. Arnold,
- Eric B. Haura,
- Ciprian Bolca,
- Ivana Holcatova,
- Vladimir Janout,
- Milica Kontic,
- Jolanta Lissowska,
- Anush Mukeria,
- Simona Ognjanovic,
- Tadeusz M. Orlowski,
- Ghislaine Scelo,
- Beata Swiatkowska,
- David Zaridze,
- Per Bakke,
- Vidar Skaug,
- Shanbeh Zienolddiny,
- Eric J. Duell,
- Lesley M. Butler,
- Woon-Puay Koh,
- Yu-Tang Gao,
- Richard Houlston,
- John McLaughlin,
- Victoria Stevens,
- David C. Nickle,
- Ma’en Obeidat,
- Wim Timens,
- Bin Zhu,
- Lei Song,
- María Soler Artigas,
- Martin D. Tobin,
- Louise V. Wain,
- Fangyi Gu,
- Jinyoung Byun,
- Ahsan Kamal,
- Dakai Zhu,
- Rachel F. Tyndale,
- Wei-Qi Wei,
- Stephen Chanock,
- Paul Brennan,
- Christopher I. Amos
Affiliations
- Xuemei Ji
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Yohan Bossé
- Department of Molecular Medicine, Laval University
- Maria Teresa Landi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Jiang Gui
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Xiangjun Xiao
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- David Qian
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Philippe Joubert
- Institut universitaire de cardiologie et de pneumologie de Québec
- Maxime Lamontagne
- Institut universitaire de cardiologie et de pneumologie de Québec
- Yafang Li
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Ivan Gorlov
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Mariella de Biasi
- Annenberg School of Communication, University of Pennsylvania
- Younghun Han
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Olga Gorlova
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Rayjean J. Hung
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto
- Xifeng Wu
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- James McKay
- International Agency for Research on Cancer, World Health Organization
- Xuchen Zong
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto
- Robert Carreras-Torres
- International Agency for Research on Cancer, World Health Organization
- David C. Christiani
- Department of Environmental Health, Harvard School of Public Health
- Neil Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Mattias Johansson
- International Agency for Research on Cancer, World Health Organization
- Geoffrey Liu
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto
- Stig E. Bojesen
- Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Demetrios Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Heike Bickeböller
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen
- Melinda C. Aldrich
- Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center
- William S. Bush
- Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center
- Adonina Tardon
- Faculty of Medicine, University of Oviedo
- Gad Rennert
- Clalit National Cancer Control Center, Carmel Medical Center
- Chu Chen
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- M. Dawn Teare
- School of Health and Related Research, University of Sheffield
- John K. Field
- Roy Castle Lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool
- Lambertus A. Kiemeney
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Philip Lazarus
- Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University
- Aage Haugen
- National Institute of Occupational Health
- Stephen Lam
- British Columbia Cancer Agency
- Matthew B. Schabath
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute
- Angeline S. Andrew
- Department of Epidemiology, Geisel School of Medicine
- Hongbing Shen
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University
- Yun-Chul Hong
- Department of Preventive Medicine, Seoul National University College of Medicine
- Jian-Min Yuan
- University of Pittsburgh Cancer Institute
- Pier A. Bertazzi
- Department of Preventive Medicine, IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico
- Angela C. Pesatori
- Department of Preventive Medicine, IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico
- Yuanqing Ye
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Nancy Diao
- Department of Environmental Health, Harvard School of Public Health
- Li Su
- Department of Environmental Health, Harvard School of Public Health
- Ruyang Zhang
- Department of Environmental Health, Harvard School of Public Health
- Yonathan Brhane
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto
- Natasha Leighl
- University Health Network—The Princess Margaret Cancer Centre
- Jakob S. Johansen
- Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Anders Mellemgaard
- Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Walid Saliba
- Clalit National Cancer Control Center, Carmel Medical Center
- Christopher Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Lynne Wilkens
- Epidemiology Program, University of Hawaii Cancer Center
- Ana Fernandez-Somoano
- Faculty of Medicine, University of Oviedo
- Guillermo Fernandez-Tardon
- Faculty of Medicine, University of Oviedo
- Erik H. F. M. van der Heijden
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Jin Hee Kim
- Department of Integrative Bioscience & Biotechnology, Sejong University
- Juncheng Dai
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University
- Zhibin Hu
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University
- Michael P. A. Davies
- Roy Castle Lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool
- Michael W. Marcus
- Roy Castle Lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool
- Hans Brunnström
- Department of Pathology, Lund University
- Jonas Manjer
- Faculty of Medicine, Lund University
- Olle Melander
- Faculty of Medicine, Lund University
- David C. Muller
- School of Public Health, St Mary’s Campus, Imperial College London
- Kim Overvad
- Faculty of Medicine, Lund University
- Antonia Trichopoulou
- Hellenic Health Foundation
- Rosario Tumino
- Cancer Registry and Histopathology Department, “Civic-M.P. Arezzo” Hospital, ASP
- Jennifer Doherty
- Department of Epidemiology, Geisel School of Medicine
- Gary E. Goodman
- Fred Hutchinson Cancer Research Center
- Angela Cox
- Department of Oncology and Metabolism, University of Sheffield
- Fiona Taylor
- Department of Oncology and Metabolism, University of Sheffield
- Penella Woll
- Department of Oncology and Metabolism, University of Sheffield
- Irene Brüske
- Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
- Judith Manz
- Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
- Thomas Muley
- Thoraxklinik at University Hospital Heidelberg
- Angela Risch
- Cancer Cluster Salzburg, University of Salzburg
- Albert Rosenberger
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen
- Kjell Grankvist
- Department of Medical Biosciences, Umeå University
- Mikael Johansson
- Department of Radiation Sciences, Umeå University
- Frances Shepherd
- Princess Margaret Cancer Centre
- Ming-Sound Tsao
- Princess Margaret Cancer Centre
- Susanne M. Arnold
- Markey Cancer Center, University of Kentucky
- Eric B. Haura
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Ciprian Bolca
- Institute of Pneumology “Marius Nasta”
- Ivana Holcatova
- 1st Faculty of Medicine, Charles University
- Vladimir Janout
- 1st Faculty of Medicine, Charles University
- Milica Kontic
- Clinical Center of Serbia, Clinic for Pulmonology, School of Medicine, University of Belgrade
- Jolanta Lissowska
- Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Institute—Oncology Center
- Anush Mukeria
- Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Centre
- Simona Ognjanovic
- International Organization for Cancer Prevention and Research
- Tadeusz M. Orlowski
- Department of Surgery, National Tuberculosis and Lung Diseases Research Institute
- Ghislaine Scelo
- International Agency for Research on Cancer, World Health Organization
- Beata Swiatkowska
- Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine
- David Zaridze
- Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Centre
- Per Bakke
- Department of Clinical Science, University of Bergen
- Vidar Skaug
- National Institute of Occupational Health
- Shanbeh Zienolddiny
- National Institute of Occupational Health
- Eric J. Duell
- Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL)
- Lesley M. Butler
- University of Pittsburgh Cancer Institute
- Woon-Puay Koh
- Duke–NUS Medical School
- Yu-Tang Gao
- Department of Epidemiology, Shanghai Cancer Institute
- Richard Houlston
- The Institute of Cancer Research
- John McLaughlin
- Public Health Ontario
- Victoria Stevens
- American Cancer Society, Inc.
- David C. Nickle
- Department of Genetics and Pharmacogenomics, Merck Research Laboratories
- Ma’en Obeidat
- Centre for Heart Lung Innovation, St Paul’s Hospital, The University of British Columbia
- Wim Timens
- Department of Pathology and Medical Biology, GRIAC, University of Groningen, University Medical Center Groningen
- Bin Zhu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Lei Song
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- María Soler Artigas
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Martin D. Tobin
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Louise V. Wain
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Fangyi Gu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Jinyoung Byun
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Ahsan Kamal
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Dakai Zhu
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Rachel F. Tyndale
- Department of Pharmacology and Toxicology, University of Toronto
- Wei-Qi Wei
- Department of Biomedical Informatics, School of Medicine, Vanderbilt University
- Stephen Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Paul Brennan
- International Agency for Research on Cancer, World Health Organization
- Christopher I. Amos
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- DOI
- https://doi.org/10.1038/s41467-018-05074-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.
