Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children

Abstract

Abstract Background and Aim We report here our experience of using pegylated granulocyte colony stimulating factor (peg‐GCSF) for peripheral blood stem cell (PBSC) mobilization in children. Methods and results A total of nine children suffering from high‐risk/relapsed solid tumors were mobilized with chemotherapy and peg‐GCSF (100 microgram/kg single dose). Mean age was 7.7 years (range 2–15 years).The mean time from peg‐GCSF administration to PBSC harvest was 9.7 days. Adequate stem cells (median dose 26.9 million/kg) could be harvested in all children by a single apheresis procedure. No major adverse events observed. Conclusion It is feasible and safe to mobilize PBSC with peg‐GCSF in children with cancer.

Keywords

• children
• mobilization
• pegylated‐GCSF
• peripheral blood stem cell