Nature Communications (Mar 2020)
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
- Li Ren Kong,
- Nur Afiqah Binte Mohamed Salleh,
- Richard Weijie Ong,
- Tuan Zea Tan,
- Nicholas L. Syn,
- Robby Miguel Goh,
- Chee Wai Fhu,
- Daniel S. W. Tan,
- N. Gopalakrishna Iyer,
- Srinivasaraghavan Kannan,
- Chandra S. Verma,
- Yaw Chyn Lim,
- Ross Soo,
- Jingshan Ho,
- Yiqing Huang,
- Joline S. J. Lim,
- Benedict Junrong Yan,
- Min En Nga,
- Seng Gee Lim,
- H. Phillip Koeffler,
- Soo Chin Lee,
- Dennis Kappei,
- Huynh The Hung,
- Boon Cher Goh
Affiliations
- Li Ren Kong
- Cancer Science Institute of Singapore, National University of Singapore
- Nur Afiqah Binte Mohamed Salleh
- Cancer Science Institute of Singapore, National University of Singapore
- Richard Weijie Ong
- Laboratory of Molecular Endocrinology, National Cancer Centre Singapore
- Tuan Zea Tan
- Cancer Science Institute of Singapore, National University of Singapore
- Nicholas L. Syn
- Cancer Science Institute of Singapore, National University of Singapore
- Robby Miguel Goh
- Department of Hematology-Oncology, National University Cancer Institute
- Chee Wai Fhu
- Cancer Science Institute of Singapore, National University of Singapore
- Daniel S. W. Tan
- Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore
- N. Gopalakrishna Iyer
- Cancer Science Institute of Singapore, National University of Singapore
- Srinivasaraghavan Kannan
- Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR)
- Chandra S. Verma
- Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR)
- Yaw Chyn Lim
- Department of Pathology, National University Health System
- Ross Soo
- Department of Hematology-Oncology, National University Cancer Institute
- Jingshan Ho
- Department of Hematology-Oncology, National University Cancer Institute
- Yiqing Huang
- Department of Hematology-Oncology, National University Cancer Institute
- Joline S. J. Lim
- Cancer Science Institute of Singapore, National University of Singapore
- Benedict Junrong Yan
- Department of Pathology, National University Health System
- Min En Nga
- Department of Pathology, National University Health System
- Seng Gee Lim
- Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- H. Phillip Koeffler
- Cancer Science Institute of Singapore, National University of Singapore
- Soo Chin Lee
- Cancer Science Institute of Singapore, National University of Singapore
- Dennis Kappei
- Cancer Science Institute of Singapore, National University of Singapore
- Huynh The Hung
- Laboratory of Molecular Endocrinology, National Cancer Centre Singapore
- Boon Cher Goh
- Cancer Science Institute of Singapore, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-020-15318-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancers.
