Communications Biology (Mar 2023)
Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors
- Marta Fontcuberta-PiSunyer,
- Ainhoa García-Alamán,
- Èlia Prades,
- Noèlia Téllez,
- Hugo Alves-Figueiredo,
- Mireia Ramos-Rodríguez,
- Carlos Enrich,
- Rebeca Fernandez-Ruiz,
- Sara Cervantes,
- Laura Clua,
- Javier Ramón-Azcón,
- Christophe Broca,
- Anne Wojtusciszyn,
- Nuria Montserrat,
- Lorenzo Pasquali,
- Anna Novials,
- Joan-Marc Servitja,
- Josep Vidal,
- Ramon Gomis,
- Rosa Gasa
Affiliations
- Marta Fontcuberta-PiSunyer
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Ainhoa García-Alamán
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Èlia Prades
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Noèlia Téllez
- CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III
- Hugo Alves-Figueiredo
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Mireia Ramos-Rodríguez
- Department of Medicine and Life Sciences, Universitat Pompeu Fabra
- Carlos Enrich
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Rebeca Fernandez-Ruiz
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Sara Cervantes
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Laura Clua
- Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Technology (BIST)
- Javier Ramón-Azcón
- Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Technology (BIST)
- Christophe Broca
- CHU Montpellier, Laboratory of Cell Therapy for Diabetes (LTCD), Hospital St-Eloi
- Anne Wojtusciszyn
- CHU Montpellier, Laboratory of Cell Therapy for Diabetes (LTCD), Hospital St-Eloi
- Nuria Montserrat
- Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Technology (BIST)
- Lorenzo Pasquali
- Department of Medicine and Life Sciences, Universitat Pompeu Fabra
- Anna Novials
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Joan-Marc Servitja
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Josep Vidal
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Ramon Gomis
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Rosa Gasa
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- DOI
- https://doi.org/10.1038/s42003-023-04627-2
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 15
Abstract
Human foreskin fibroblasts are directly reprogrammed into insulin-producing cells using 5 pancreatic transcription factors, without pluripotency induction.
