Nature Communications (Dec 2022)
Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation
- Gi Uk Jeong,
- Hyung-Jun Kwon,
- Wern Hann Ng,
- Xiang Liu,
- Hyun Woo Moon,
- Gun Young Yoon,
- Hye Jin Shin,
- In-Chul Lee,
- Zheng Lung Ling,
- Alanna G. Spiteri,
- Nicholas J. C. King,
- Adam Taylor,
- Ji Soo Chae,
- Chonsaeng Kim,
- Dae-Gyun Ahn,
- Kyun-Do Kim,
- Young Bae Ryu,
- Seong-Jun Kim,
- Suresh Mahalingam,
- Young-Chan Kwon
Affiliations
- Gi Uk Jeong
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- Hyung-Jun Kwon
- Department of Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology
- Wern Hann Ng
- Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University
- Xiang Liu
- Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University
- Hyun Woo Moon
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- Gun Young Yoon
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- Hye Jin Shin
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- In-Chul Lee
- Department of Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology
- Zheng Lung Ling
- Viral Immunopathology Laboratory, The Charles Perkins Centre, The University of Sydney
- Alanna G. Spiteri
- Viral Immunopathology Laboratory, The Charles Perkins Centre, The University of Sydney
- Nicholas J. C. King
- Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University
- Adam Taylor
- Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University
- Ji Soo Chae
- Department of Life Sciences, PerkinElmer
- Chonsaeng Kim
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- Dae-Gyun Ahn
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- Kyun-Do Kim
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- Young Bae Ryu
- Department of Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology
- Seong-Jun Kim
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- Suresh Mahalingam
- Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University
- Young-Chan Kwon
- Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology
- DOI
- https://doi.org/10.1038/s41467-022-35225-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
SARS-CoV-2 pathogenesis is very complex and not fully understood yet. Here, Jeong et al. show that intranasally infected K18-hACE2 transgenic mice develop ocular infection and retinal inflammation, while intratracheal infection results in the dissemination of SARS-CoV-2 from mouse lungs to their brain and eyes via unidirectional route and confirm the tissue tropism in Syrian hamster model.
