Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

Jinghua Wang; Jinghua Wang; Shushan Yan; Jinghan Yang; Jinghan Yang; Hongying Lu; Donghua Xu; Donghua Xu; Zengyan Wang

doi:10.3389/fimmu.2019.03129

Frontiers in Immunology (Jan 2020)

Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

Jinghua Wang,
Jinghua Wang,
Shushan Yan,
Jinghan Yang,
Jinghan Yang,
Hongying Lu,
Donghua Xu,
Donghua Xu,
Zengyan Wang

Affiliations

Jinghua Wang: Clinical Medicine College, Weifang Medical University, Weifang, China
Jinghua Wang: Department of Rheumatology, The Affiliated Hospital of Weifang Medical University, Weifang, China
Shushan Yan: Department of Gastrointestinal and Anal Diseases Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, China
Jinghan Yang: Clinical Medicine College, Weifang Medical University, Weifang, China
Jinghan Yang: Department of Rheumatology, The Affiliated Hospital of Weifang Medical University, Weifang, China
Hongying Lu: Functional Laboratory, Clinical Medicine College of Weifang Medical University, Weifang, China
Donghua Xu: Clinical Medicine College, Weifang Medical University, Weifang, China
Donghua Xu: Department of Rheumatology, The Affiliated Hospital of Weifang Medical University, Weifang, China
Zengyan Wang: Department of Operating Room, Zhucheng People's Hospital, Zhucheng, China

DOI: https://doi.org/10.3389/fimmu.2019.03129
Journal volume & issue: Vol. 10

Abstract

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Rheumatoid arthritis is a common systemic and autoimmune disease characterized by symmetrical and inflammatory destruction of distal joints. Its primary pathological characters are synovitis and vasculitis. Accumulating studies have implicated the critical role of non-coding RNAs (ncRNAs) in inflammation and autoimmune regulation, primarily including microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). NcRNAs are significant regulators in distinct physiological and pathophysiological processes. Many validated non-coding RNAs have been identified as promising biomarkers for the diagnosis and treatment of RA. This review will shed some light on RA pathogenesis and be helpful for identifying potential ncRNA biomarkers for RA.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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