Design and synthesis of water-solube chlorin derivatives as photosensitizer for photodynamic therapy

Abstract

As a new tumor therapy with low side effects, photodynamic therapy (PDT) uses a certain wavelength of light to excite the photosensitizer enriched in the tumor site to produce biological and chemical toxic ROS, thereby killing tumor cells and inhibiting tumor growth. In this article, we prepared new photosensitizers 3-hexyloxymethyl-3-devinylchlorin e4 disodium salt (CEFO) and 3-n-hexylaminomethyl-3-devinylchlorin e4 disodium salt (CEFN) to investigate its anti-cancer effects and inhibition mechanism on the murine mammary carcinoma 4T1 cancer cells in vitro and in vivo. The results indicate that CEFO, with high phototoxicity and low dark toxicity, is capable of inhibiting the proliferation and metastasis of 4T1 cancer cells.

Keywords

• Photodynamic therapy
• Photosensitizer
• Cancer cell
• Apoptosis
• Mitochondria