Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients

Yuan Lin; Lin-Lin Li; Wei Nie; Xiaolei Liu; Avital Adler; Chi Xiao; Fujian Lu; Liping Wang; Hua Han; Xianhua Wang; Wen-Biao Gan; Heping Cheng

doi:10.1038/s41467-019-13142-0

Nature Communications (Nov 2019)

Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients

Yuan Lin,
Lin-Lin Li,
Wei Nie,
Xiaolei Liu,
Avital Adler,
Chi Xiao,
Fujian Lu,
Liping Wang,
Hua Han,
Xianhua Wang,
Wen-Biao Gan,
Heping Cheng

Affiliations

Yuan Lin: State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University
Lin-Lin Li: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences
Wei Nie: State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University
Xiaolei Liu: The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Avital Adler: Skirball Institute of Biomolecular Medicine, Department of Neuroscience and Physiology, Department of Anesthesiology, Neuroscience Institute, New York University School of Medicine
Chi Xiao: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences
Fujian Lu: State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University
Liping Wang: The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Hua Han: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences
Xianhua Wang: State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University
Wen-Biao Gan: Skirball Institute of Biomolecular Medicine, Department of Neuroscience and Physiology, Department of Anesthesiology, Neuroscience Institute, New York University School of Medicine
Heping Cheng: State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University

DOI: https://doi.org/10.1038/s41467-019-13142-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Mitochondrial calcium signaling plays an important role in neuronal bioenergetics yet its regulation by brain activity in vivo is not understood. Here, the authors show that mitochondrial and cytosolic calcium transients are dynamically coupled as a function of brain activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal