Nature Communications (Mar 2022)

Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy

  • Dongxiao Zhang,
  • Danni Zhong,
  • Jiang Ouyang,
  • Jian He,
  • Yuchen Qi,
  • Wei Chen,
  • Xingcai Zhang,
  • Wei Tao,
  • Min Zhou

DOI
https://doi.org/10.1038/s41467-022-28744-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Protecting the whole small intestine from radiation-induced intestinal injury during the radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Here the authors use a natural microalga to readily construct an oral delivery system to achieve effective radioprotection for the small intestine.