Nature Communications (May 2018)

Engineering modular intracellular protein sensor-actuator devices

  • Velia Siciliano,
  • Breanna DiAndreth,
  • Blandine Monel,
  • Jacob Beal,
  • Jin Huh,
  • Kiera L Clayton,
  • Liliana Wroblewska,
  • AnneMarie McKeon,
  • Bruce D. Walker,
  • Ron Weiss

DOI
https://doi.org/10.1038/s41467-018-03984-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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Synthetic biology principles are often used to design circuits that tune gene expression in response to changes in intracellular environments. Here the authors design a modular platform for intracellular protein sensing devices with transcriptional output.