Nature Communications (Nov 2016)

Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway

  • Fumiaki Ando,
  • Eisei Sohara,
  • Tetsuji Morimoto,
  • Naofumi Yui,
  • Naohiro Nomura,
  • Eriko Kikuchi,
  • Daiei Takahashi,
  • Takayasu Mori,
  • Alain Vandewalle,
  • Tatemitsu Rai,
  • Sei Sasaki,
  • Yoshiaki Kondo,
  • Shinichi Uchida

DOI
https://doi.org/10.1038/ncomms13636
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway.