Communications Biology (Feb 2021)
Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
- Abhinay Gontu,
- Sreenidhi Srinivasan,
- Eric Salazar,
- Meera Surendran Nair,
- Ruth H. Nissly,
- Denver Greenawalt,
- Ian M. Bird,
- Catherine M. Herzog,
- Matthew J. Ferrari,
- Indira Poojary,
- Robab Katani,
- Scott E. Lindner,
- Allen M. Minns,
- Randall Rossi,
- Paul A. Christensen,
- Brian Castillo,
- Jian Chen,
- Todd N. Eagar,
- Xin Yi,
- Picheng Zhao,
- Christopher Leveque,
- Randall J. Olsen,
- David W. Bernard,
- Jimmy Gollihar,
- Suresh V. Kuchipudi,
- James M. Musser,
- Vivek Kapur
Affiliations
- Abhinay Gontu
- Department of Veterinary and Biomedical Sciences, Pennsylvania State University
- Sreenidhi Srinivasan
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Eric Salazar
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Meera Surendran Nair
- Department of Veterinary and Biomedical Sciences, Pennsylvania State University
- Ruth H. Nissly
- Department of Veterinary and Biomedical Sciences, Pennsylvania State University
- Denver Greenawalt
- Department of Veterinary and Biomedical Sciences, Pennsylvania State University
- Ian M. Bird
- Department of Veterinary and Biomedical Sciences, Pennsylvania State University
- Catherine M. Herzog
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Matthew J. Ferrari
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Indira Poojary
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Robab Katani
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Scott E. Lindner
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Allen M. Minns
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Randall Rossi
- Huck Institutes of the Life Sciences, Pennsylvania State University
- Paul A. Christensen
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Brian Castillo
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Jian Chen
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Todd N. Eagar
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Xin Yi
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Picheng Zhao
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Christopher Leveque
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Randall J. Olsen
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- David W. Bernard
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Jimmy Gollihar
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Suresh V. Kuchipudi
- Department of Veterinary and Biomedical Sciences, Pennsylvania State University
- James M. Musser
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Vivek Kapur
- Huck Institutes of the Life Sciences, Pennsylvania State University
- DOI
- https://doi.org/10.1038/s42003-021-01813-y
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 9
Abstract
Gontu et al. conducted a longitudinal study in COVID patients in which they assessed the response trajectories of antibodies directed to the SARS-CoV-2 surface spike glycoprotein and in vitro SARS-CoV-2 live virus neutralizing titers. Their measurements demonstrate the presence of an optimum window for convalescent plasma donation as well as predictions of the most suitable donor type.
