Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy

Abstract

Objective: to study the characteristics of manifestations of hormonal abnormalities in women with juvenile myoclonic epilepsy (JME) and to comparatively analyze identified syndromes.Patients and methods. Hormonal disorders were analyzed in 48 reproductive-aged women with JME, who had received antiepileptic drug (AED) mono- and bitherapy during one or more years.Results. 66.7% of the patients were found to have ovarian hormonal dysfunction manifesting itself as the development of polycystic ovary syndrome, hypogonadism, isolated hyperandrogenism, and hypoprogesteronemia. Clinically detected syndromes frequently appeared as menstrual irregularity in 29% of the patients. Comparative analysis of hormone-dependent syndromes showed that there were no differences in the clinical features of JME, but the earliest age at onset in isolated hyperandrogenism, and no patients with menstrual irregularity in the presence of isolated hypoprogesteronemia. The use of different AEDs had no impact on the incidence of hormonal abnormalities, which requires further investigation and its inclusion of a greater number of patients receiving various AEDs.

Keywords

• juvenile myoclonic epilepsy
• antiepileptic therapy
• follicle-stimulating hormone
• luteinizing hormone
• estradiol
• testosterone
• progesterone
• polycystic ovary syndrome
• hyperandrogenism, hypoprogesteronemia
• hypogonadism