Journal of Clinical Medicine (Jun 2022)

The Prognostic Role of Polysomnography Parameters in Heart Failure Patients with Previous Decompensation

  • Elena Medvedeva,
  • Lyudmila Korostovtseva,
  • Mihail Bochkarev,
  • Anastasiya Shumeiko,
  • Aelita Berezina,
  • Maria Simonenko,
  • Yulia Sazonova,
  • Andrey Kozlenok,
  • Yurii Sviryaev

DOI
https://doi.org/10.3390/jcm11133656
Journal volume & issue
Vol. 11, no. 13
p. 3656

Abstract

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Background: Sleep-disordered breathing (SDB) is a widespread comorbidity in patients with chronic heart failure (HF) and may have a deleterious effect on the pathogenesis of HF. We aimed to evaluate the prognostic role of polysomnography parameters in HF patients with previous decompensation. Methods: 123 patients were included in the prospective cohort study. In addition to the standard examination, all patients underwent polysomnography (PSG). Results: The Kaplan–Meier analysis showed the incidence of the combined endpoint differs between LVEF categories ≤25.5% vs. >25.5% (χ2 = 9.6, log rank p = 0.002), NTpro-BNP > 680 vs. ≤680 pg/mL (χ2 = 12.7, log rank p = 0.001), VO2peak categories 2 = 14.2, log rank p = 0.001), VE/VCO2 slope ≥38.5 vs. 2 = 14.5, log rank p = 0.001), wake after sleep onset >40 min vs. ≤40 min (χ2 = 9.7, log rank p = 0.03), and sleep stage 2 (S2) 2 = 12.4, log rank p = 0.001). Conclusion: Among the PSG parameters, WASO > 40 min and S2 2 slope, lower LVEF, and VO2peak were also independent factors of a poor prognosis.

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