Nature Communications (Jan 2020)

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

  • Tom G. Richardson,
  • Gibran Hemani,
  • Tom R. Gaunt,
  • Caroline L. Relton,
  • George Davey Smith

DOI
https://doi.org/10.1038/s41467-019-13921-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Gene expression and how genetic variants can influence gene expression are tissue-specific processes with important implications for phenotypes. Here, Richardson et al. use eQTL data from GTEx and the eQTLGen project in a two-sample SMR + HEIDI framework for causal inference of gene expression associations with complex trait.