Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
Haogang Zhu,
Shuo Liu,
Zijing Guo,
Kun Yan,
Jiancang Shen,
Zhiyong Zhang,
Jian Chen,
Yachong Guo,
Lizhe Liu,
Xinglong Wu
Affiliations
Haogang Zhu
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Shuo Liu
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Zijing Guo
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Kun Yan
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Jiancang Shen
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Zhiyong Zhang
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Corresponding author
Jian Chen
National Laboratory of Solid States Microstructures and Research Institute of Superconductor Electronics, Nanjing University, Nanjing 210093, China
Yachong Guo
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Kuang Yaming Honors School, Nanjing University, Nanjing 210023, China; Leibniz-Institut für Polymerforschung Dresden, Hohe Strasse 6, 01069 Dresden, Germany; Corresponding author
Lizhe Liu
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Corresponding author
Xinglong Wu
National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Corresponding author
Summary: Allergic diseases are closely related to degranulation and release of histamine and difficult to diagnose because non-allergic diseases also exhibit the same clinical symptoms as allergy. Here, we report direct, rapid, and ultrasensitive detection of histamine using low-frequency molecular torsion Raman spectroscopy. We show that the low-frequency (3) of histamine reaches 10−8 g/L in water and 10−6 g/L in serum. This scheme thus opens new lines of inquiry regarding the clinical diagnosis of allergic diseases.
