Nature Communications (Apr 2019)

Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains

  • Simone Heber,
  • Imre Gáspár,
  • Jan-Niklas Tants,
  • Johannes Günther,
  • Sandra M. Fernandez Moya,
  • Robert Janowski,
  • Anne Ephrussi,
  • Michael Sattler,
  • Dierk Niessing

DOI
https://doi.org/10.1038/s41467-019-09655-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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The Staufen family of RNA-binding proteins are conserved microtubule dependent mRNA transporter factors. Here the authors use biochemical and functional approaches to characterize the RNA-binding properties of mouse Staufen 2 and study the mRNA binding capacity of its two domains dsRBDs 1 and 2.