Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma

Cancer Management and Research. 2019;Volume 11:8219-8227

 

Journal Homepage

Journal Title: Cancer Management and Research

ISSN: 1179-1322 (Online)

Publisher: Dove Medical Press

LCC Subject Category: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Feng J
Zhan Y
Zhang Y
Zheng H
Wang W
Fan S

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 16 weeks

 

Abstract | Full Text

Juan Feng,1,2 Yuting Zhan,1 Yuting Zhang,1 Hongmei Zheng,1 Weiyuan Wang,3 Songqing Fan1 1Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Clinical Laboratory of Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, People’s Republic of China; 3Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Songqing FanDepartment of Pathology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, People’s Republic of ChinaEmail [email protected]: Heat shock proteins (HSPs) are a large family of chaperones implicating in occurrence and progression of tumor. In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma. HSP70 is also an important part of this family and whether the alterations of HSP10 and HSP70 expression and their common expression correlates with carcinogenesis and progression of nasopharyngeal carcinoma (NPC) has not been reported.Method: In this study, we investigate the correlation between the expression of HSP10 and HSP70 and clinicopathological characteristics in NPC by immunohistochemistry (IHC).Results: Results indicated that positive expression of HSP10 and HSP70 was higher in NPC tissues (both P<0.001). Positive expression of HSP10 and HSP70 proteins, and common positive expression of the two HSPs analyzed in advanced clinical stages were higher than that in early clinical stages (All P<0.05). There was significantly higher expression of HSP10, HSP70, and common expression in NPC with LNM (lymph node metastasis) compared with NPC without LNM (All P<0.05). Interestingly, positive expression of HSP10 and HSP70 proteins and common expression had an evidently inverse correlation with survival status (All P<0.05). Spearman’s correlation analysis showed expression of HSP10 was positively associated with HSP70 (r=0.407, P<0 0.001). Kaplan–Meier analysis showed that the overall survival rates for NPC patients with positive expression of HSP10 and HSP70 and common expression were significantly lower than these patients with negative expression (All P<0.05). Furthermore, positive expression of HSP10 and HSP70 proteins was identified as independent poor prognostic factors for NPC patients (both P<0.05) by Cox regression analysis.Conclusion: In conclusion, HSP10 and HSP70 can serve as the poor prognostic factors for NPC patients.Keywords: nasopharyngeal carcinoma, HSP10, HSP70, prognosis