Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization

Rafeek Thahakoya; Koren E. Roach; Misung Han; Rupsa Bhattacharjee; Fei Jiang; Johanna Luitjens; Emma Bahroos; Valentina Pedoia; Richard B. Souza; Sharmila Majumdar

Osteoarthritis and Cartilage Open (Dec 2024)

Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization

Rafeek Thahakoya,
Koren E. Roach,
Misung Han,
Rupsa Bhattacharjee,
Fei Jiang,
Johanna Luitjens,
Emma Bahroos,
Valentina Pedoia,
Richard B. Souza,
Sharmila Majumdar

Affiliations

Rafeek Thahakoya: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA; Corresponding author. 1700 4th Street, #201, San Francisco, CA 94158, USA.
Koren E. Roach: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA; Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Calgary, Alberta, Canada
Misung Han: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
Rupsa Bhattacharjee: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
Fei Jiang: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
Johanna Luitjens: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
Emma Bahroos: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
Valentina Pedoia: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
Richard B. Souza: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, USA
Sharmila Majumdar: Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA

Journal volume & issue: Vol. 6, no. 4
p. 100538

Abstract

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Objective: To study the longitudinal changes of cartilage T1ρ and T2 relaxation time measurements in hip-OA patients. Methods: A calibration study compared two scanner data, Scanner-1 (GE Discovery MR750 3.0T) with unilateral acquisition protocol and Scanner-2 (GE Signa Premier 3.0T) with bilateral acquisition protocol, using nine subjects(average age = 40.33 ± 13.53 years, 5 females), including one hip-OA subject. Quantified parameters from the Scanner-2 were adjusted using voxel-based relaxometry(VBR) and Z-score normalization to reduce the inter-scanner variability. Eighteen hip-OA Subjects (age = 53.11 ± 14.96 years, 12 females) were recruited to the longitudinal variability study from 2016, comprising five assessments at 1-year intervals. Baseline to 3rd-year data used unilateral acquisition with Scanner-1, while 4th-year data used bilateral acquisition with Scanner-2. A linear mixed-effects model(LME) assessed trajectory analyses, with acquisition year, age, sex, body mass index(BMI), and Kellgren-Lawrence(KL) score as predictor variables and cartilage mean T1ρ and T2 values as outcomes. Results: VBR analysis after Z-score normalization showed that only a few of the whole cartilage voxels had significant differences in T1ρ(femur-2.36 % and acetabular-3.23 %) and T2 (femur-2.30 % and acetabular-2.94 %) values between the scanners. The LME analysis showed that the BMI predictor variable was significantly correlated with the femur T1ρ (p < 0.0001) and T2 (p < 0.0001) and acetabular T1ρ (p < 0.0001) and T2 (p < 0.0001) cartilage region. Conclusion: The calibration study demonstrated the effectiveness of VBR and Z-score normalization in reducing inter-scanner variability. The longitudinal study revealed a significant correlation between T1ρ and T2 values of the cartilage and BMI; also the T1ρ and T2 values increased over time in some of the cartilage subregions.

Published in Osteoarthritis and Cartilage Open

ISSN: 2665-9131 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system
Website: https://www.journals.elsevier.com/osteoarthritis-and-cartilage-open/

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