Nature Communications (Aug 2020)

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

  • Jasper Iske,
  • Midas Seyda,
  • Timm Heinbokel,
  • Ryoichi Maenosono,
  • Koichiro Minami,
  • Yeqi Nian,
  • Markus Quante,
  • Christine S. Falk,
  • Haruhito Azuma,
  • Friederike Martin,
  • João F. Passos,
  • Claus U. Niemann,
  • Tamara Tchkonia,
  • James L. Kirkland,
  • Abdallah Elkhal,
  • Stefan G. Tullius

DOI
https://doi.org/10.1038/s41467-020-18039-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs.