Nature Communications (Aug 2020)
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
Abstract
Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs.