Nature Communications (Apr 2019)
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
- Arie B. Brinkman,
- Serena Nik-Zainal,
- Femke Simmer,
- F. Germán Rodríguez-González,
- Marcel Smid,
- Ludmil B. Alexandrov,
- Adam Butler,
- Sancha Martin,
- Helen Davies,
- Dominik Glodzik,
- Xueqing Zou,
- Manasa Ramakrishna,
- Johan Staaf,
- Markus Ringnér,
- Anieta Sieuwerts,
- Anthony Ferrari,
- Sandro Morganella,
- Thomas Fleischer,
- Vessela Kristensen,
- Marta Gut,
- Marc J. van de Vijver,
- Anne-Lise Børresen-Dale,
- Andrea L. Richardson,
- Gilles Thomas,
- Ivo G. Gut,
- John W. M. Martens,
- John A. Foekens,
- Michael R. Stratton,
- Hendrik G. Stunnenberg
Affiliations
- Arie B. Brinkman
- Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University
- Serena Nik-Zainal
- Wellcome Trust Sanger Institute
- Femke Simmer
- Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University
- F. Germán Rodríguez-González
- Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Department of Medical Oncology, Erasmus University Medical Center
- Marcel Smid
- Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Department of Medical Oncology, Erasmus University Medical Center
- Ludmil B. Alexandrov
- Wellcome Trust Sanger Institute
- Adam Butler
- Wellcome Trust Sanger Institute
- Sancha Martin
- Wellcome Trust Sanger Institute
- Helen Davies
- Wellcome Trust Sanger Institute
- Dominik Glodzik
- Wellcome Trust Sanger Institute
- Xueqing Zou
- Wellcome Trust Sanger Institute
- Manasa Ramakrishna
- Wellcome Trust Sanger Institute
- Johan Staaf
- Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University
- Markus Ringnér
- Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University
- Anieta Sieuwerts
- Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Department of Medical Oncology, Erasmus University Medical Center
- Anthony Ferrari
- Synergie Lyon Cancer, Centre Léon Bérard
- Sandro Morganella
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- Thomas Fleischer
- Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Vessela Kristensen
- Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Marta Gut
- Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona
- Marc J. van de Vijver
- Department of Pathology, Academic Medical Center
- Anne-Lise Børresen-Dale
- Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Andrea L. Richardson
- Department of Pathology, Brigham and Women’s Hospital
- Gilles Thomas
- Synergie Lyon Cancer, Centre Léon Bérard
- Ivo G. Gut
- Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona
- John W. M. Martens
- Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Department of Medical Oncology, Erasmus University Medical Center
- John A. Foekens
- Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Department of Medical Oncology, Erasmus University Medical Center
- Michael R. Stratton
- Wellcome Trust Sanger Institute
- Hendrik G. Stunnenberg
- Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University
- DOI
- https://doi.org/10.1038/s41467-019-09828-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that these domains fuel CpG island hypermethylation.
