Frontiers in Public Health (Jul 2021)
The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study
- He Zhou,
- He Zhou,
- Xiaoli Sun,
- Yiding Wang,
- Yufeng Ye,
- Hanwei Chen,
- Qingsong Chen,
- Guanhao He,
- Jiaqi Wang,
- Jiaqi Wang,
- Xin Liu,
- Moran Dong,
- Moran Dong,
- Dengzhou Chen,
- Dengzhou Chen,
- Guimin Chen,
- Guimin Chen,
- Lixia Yuan,
- Lixia Yuan,
- Jianpeng Xiao,
- Jianxiong Hu,
- Weilin Zeng,
- Zuhua Rong,
- Qianqian Zhang,
- Mengya Zhou,
- Lingchuan Guo,
- Yanyun Lv,
- Jingjie Fan,
- Yudong Pu,
- Wenjun Ma,
- Bo Zhang,
- Bo Zhang,
- Tao Liu,
- Tao Liu,
- Tao Liu
Affiliations
- He Zhou
- School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
- He Zhou
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Xiaoli Sun
- Gynecology Department, Guangdong Women and Children Hospital, Guangzhou, China
- Yiding Wang
- Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, China
- Yufeng Ye
- Guangzhou Panyu Central Hospital, Guangzhou, China
- Hanwei Chen
- Guangzhou Panyu Central Hospital, Guangzhou, China
- Qingsong Chen
- School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
- Guanhao He
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Jiaqi Wang
- School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
- Jiaqi Wang
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Xin Liu
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Moran Dong
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Moran Dong
- School of Public Health, Southern Medical University, Guangzhou, China
- Dengzhou Chen
- School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
- Dengzhou Chen
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Guimin Chen
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Guimin Chen
- School of Public Health, Southern Medical University, Guangzhou, China
- Lixia Yuan
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Lixia Yuan
- School of Public Health, Sun Yat-sen University, Guangzhou, China
- Jianpeng Xiao
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Jianxiong Hu
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Weilin Zeng
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Zuhua Rong
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Qianqian Zhang
- Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, China
- Mengya Zhou
- Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, China
- Lingchuan Guo
- State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China
- Yanyun Lv
- Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, China
- Jingjie Fan
- 0Department of Prevention and Health Care, Shenzhen Maternity & Child Health Care Hospital, Southern Medical University, Shenzhen, China
- Yudong Pu
- 1Songshan Lake Central Hospital of Dongguan City, Dongguan, China
- Wenjun Ma
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Bo Zhang
- Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, China
- Bo Zhang
- School of Public Health, Southern Medical University, Guangzhou, China
- Tao Liu
- School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China
- Tao Liu
- Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
- Tao Liu
- 2School of Medicine, Jinan University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fpubh.2021.679406
- Journal volume & issue
-
Vol. 9
Abstract
Background: Previous studies have demonstrated the embryotoxicity and fetotoxicity of thallium (Tl). However, the effects of prenatal exposure to Tl on birth weight and placental weight and the mediating role of placental weight in the association of Tl with birth weight remain unclear.Methods: We recruited 2,748 participants from the ongoing Prenatal Environment and Offspring Health Cohort (PEOH Cohort) study, which was initiated in 2016 in Guangzhou, China. The Tl concentrations in maternal urine samples collected during the first and third trimester were determined by inductively coupled plasma mass spectrometry. Birth weight and placental weight were extracted from maternal medical records.Results: Pregnant women exposed to the highest tertile of Tl in the first trimester (β = −42.7 g, 95% CI: −82.3, −3.1 g) and third trimester (β = −50.6 g, 95% CI: −99.0, −2.3 g) had babies with lower birth weights than those exposed to the lowest tertile. We also found significant negative associations of exposure to Tl concentrations in the first and third trimester with placental weight. Mediation analyses showed that 50.3% (95% CI: 15.9, 79.2%) and 33.5% (95% CI: 1.3, 80.3%) of the effects of Tl exposure in the first and third trimester on birth weight were mediated by decreased placental weight.Conclusion: Our results suggest that prenatal exposure to Tl is negatively associated with birth weight and that this association may be mediated by decreased placental weight.
Keywords
