Molecular & Cellular Oncology (Mar 2020)

Targeting MYC through WDR5

  • Lance R. Thomas,
  • Clare M. Adams,
  • Stephen W. Fesik,
  • Christine M. Eischen,
  • William P. Tansey

DOI
https://doi.org/10.1080/23723556.2019.1709388
Journal volume & issue
Vol. 7, no. 2

Abstract

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The oncoprotein transcription factor MYC is overexpressed in most cancers and is responsible for hundreds of thousands of cancer deaths worldwide every year. MYC is also a highly validated – but currently undruggable – anti-cancer target. We recently showed that breaking the interaction of MYC with its chromatin co-factor WD repeat-containing protein 5 (WDR5) promotes tumor regression in mouse xenografts, laying the foundation for a new strategy to inhibit MYC in the clinic.

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