Pharmaceutical Technology in Hospital Pharmacy (Nov 2017)

Differences in Disinfection Protocols of Raw Material Vials Intended for the Production of Parenteral Nutrition Mixtures

  • Humbert Caroline,
  • Cros Cyrille,
  • Bordenave Joelle,
  • Benoit Guy

DOI
https://doi.org/10.1515/pthp-2017-0020
Journal volume & issue
Vol. 2, no. 3
pp. 131 – 136

Abstract

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Preparation of parenteral nutrition (PN) mixtures is performed in a controlled atmosphere area (CAA) under a laminar flow hood. In 2014 and 2015 quality controls have revealed contaminations of PN bags by Bacillus. The different products used to avoid this contamination were Aniosurf premium® (prewash), ethanol (disinfection), and Aseptanios Terminal HPH® (aerosolization). The purpose of this study was to test the efficiency of disinfection on raw materials vials by different products before introduction in the CAA.

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