Nature Communications (Feb 2023)
Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes
- Antonio Citro,
- Alessia Neroni,
- Cataldo Pignatelli,
- Francesco Campo,
- Martina Policardi,
- Matteo Monieri,
- Silvia Pellegrini,
- Erica Dugnani,
- Fabio Manenti,
- Maria Chiara Maffia,
- Libera Valla,
- Elisabeth Kemter,
- Ilaria Marzinotto,
- Cristina Olgasi,
- Alessia Cucci,
- Antonia Follenzi,
- Vito Lampasona,
- Eckhard Wolf,
- Lorenzo Piemonti
Affiliations
- Antonio Citro
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Alessia Neroni
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Cataldo Pignatelli
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Francesco Campo
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Martina Policardi
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Matteo Monieri
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Silvia Pellegrini
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Erica Dugnani
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Fabio Manenti
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Maria Chiara Maffia
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Libera Valla
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Elisabeth Kemter
- Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich
- Ilaria Marzinotto
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Cristina Olgasi
- Department of Health Sciences, School of Medicine, University of Piemonte Orientale
- Alessia Cucci
- Department of Health Sciences, School of Medicine, University of Piemonte Orientale
- Antonia Follenzi
- Department of Health Sciences, School of Medicine, University of Piemonte Orientale
- Vito Lampasona
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- Eckhard Wolf
- Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich
- Lorenzo Piemonti
- San Raffaele Diabetes Research Institute, IRCCS San Raffaele Scientific Institute
- DOI
- https://doi.org/10.1038/s41467-023-36582-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Cell therapy for diabetes requires the combination of bioengineering and new sources of beta cells. Here, the authors report a self-assembly platform based on neonatal pig islets, human endothelial cells and native organ extracellular matrix, which improves ex vivo islet maturation and in vivo function in a mouse model of diabetes.
