Nature Communications (Mar 2019)
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02
- Christos Tziotzios,
- Christos Petridis,
- Nick Dand,
- Chrysanthi Ainali,
- Jake R. Saklatvala,
- Venu Pullabhatla,
- Alexandros Onoufriadis,
- Rashida Pramanik,
- David Baudry,
- Sang Hyuck Lee,
- Kristie Wood,
- Lu Liu,
- Seth Seegobin,
- Gregory A. Michelotti,
- Su M. Lwin,
- Evangelos A. A. Christou,
- Charles J. Curtis,
- Emanuele de Rinaldis,
- Alka Saxena,
- Susan Holmes,
- Matthew Harries,
- Ioulios Palamaras,
- Fiona Cunningham,
- Gregory Parkins,
- Manjit Kaur,
- Paul Farrant,
- Andrew McDonagh,
- Andrew Messenger,
- Jennifer Jones,
- Victoria Jolliffe,
- Iaisha Ali,
- Michael Ardern-Jones,
- Charles Mitchell,
- Nigel Burrows,
- Ravinder Atkar,
- Cedric Banfield,
- Anton Alexandroff,
- Caroline Champagne,
- Hywel L. Cooper,
- Sergio Vañó-Galván,
- Ana Maria Molina-Ruiz,
- Nerea Ormaechea Perez,
- Girish K. Patel,
- Abby Macbeth,
- Melanie Page,
- Alyson Bryden,
- Megan Mowbray,
- Shyamal Wahie,
- Keith Armstrong,
- Nicola Cooke,
- Mark Goodfield,
- Irene Man,
- David de Berker,
- Giles Dunnill,
- Anita Takwale,
- Archana Rao,
- Tee-Wei Siah,
- Rodney Sinclair,
- Martin S. Wade,
- Ncoza C. Dlova,
- Jane Setterfield,
- Fiona Lewis,
- Kapil Bhargava,
- Niall Kirkpatrick,
- Xavier Estivill,
- Catherine M. Stefanato,
- Carsten Flohr,
- Timothy Spector,
- Fiona M. Watt,
- Catherine H. Smith,
- Jonathan N. Barker,
- David A. Fenton,
- Michael A. Simpson,
- John A. McGrath
Affiliations
- Christos Tziotzios
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Christos Petridis
- Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital
- Nick Dand
- Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital
- Chrysanthi Ainali
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Jake R. Saklatvala
- Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital
- Venu Pullabhatla
- UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust
- Alexandros Onoufriadis
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Rashida Pramanik
- UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust
- David Baudry
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Sang Hyuck Lee
- NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, Denmark Hill Campus
- Kristie Wood
- UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust
- Lu Liu
- National Diagnostic EB Laboratory, St. Thomas Hospital
- Seth Seegobin
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Gregory A. Michelotti
- Metabolon, Inc.
- Su M. Lwin
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Evangelos A. A. Christou
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Charles J. Curtis
- UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust
- Emanuele de Rinaldis
- UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust
- Alka Saxena
- UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust
- Susan Holmes
- Alan Lyell Centre for Dermatology, Queen Elizabeth University Hospital
- Matthew Harries
- The Dermatology Centre, The University of Manchester, Salford Royal NHS Foundation Trust
- Ioulios Palamaras
- Department of Dermatology, Barnet General Hospital, Royal Free Foundation Trust
- Fiona Cunningham
- Alan Lyell Centre for Dermatology, Queen Elizabeth University Hospital
- Gregory Parkins
- Alan Lyell Centre for Dermatology, Queen Elizabeth University Hospital
- Manjit Kaur
- Department of Dermatology, Solihull Hospital
- Paul Farrant
- Department of Dermatology, Brighton and Sussex University Hospitals NHS Trust
- Andrew McDonagh
- Department of Dermatology, Royal Hallamshire Hospital
- Andrew Messenger
- Department of Dermatology, Royal Hallamshire Hospital
- Jennifer Jones
- Department of Dermatology, Royal Free Hospital
- Victoria Jolliffe
- Department of Dermatology, Royal London Hospital, Barts Health NHS Trust
- Iaisha Ali
- Department of Dermatology, Imperial College Healthcare NHS Trust
- Michael Ardern-Jones
- Department of Dermatology, University Hospitals Southampton NHS Foundation Trust
- Charles Mitchell
- Department of Dermatology, Portsmouth Hospitals NHS Trust
- Nigel Burrows
- Department of Dermatology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust
- Ravinder Atkar
- Department of Dermatology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust
- Cedric Banfield
- Department of Dermatology, Peterborough City Hospital
- Anton Alexandroff
- Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary
- Caroline Champagne
- Department of Dermatology, The Churchill Hospital
- Hywel L. Cooper
- Department of Dermatology, Portsmouth Hospitals NHS Trust
- Sergio Vañó-Galván
- Trichology Unit, Dermatology Department, Ramon Y Cajal Hospital, University of Alcala, IRYCIS
- Ana Maria Molina-Ruiz
- Hospital Universitario Fundación Jiménez Díaz
- Nerea Ormaechea Perez
- Department of Dermatology, Hospital Donostia
- Girish K. Patel
- Hywel Dda University Health Board
- Abby Macbeth
- Department of Dermatology, Norfolk & Norwich University Hospitals NHS Foundation Trust
- Melanie Page
- Department of Dermatology, Norfolk & Norwich University Hospitals NHS Foundation Trust
- Alyson Bryden
- Department of Dermatology, Ninewells Hospital
- Megan Mowbray
- Department of Dermatology, Queen Margaret Hospital
- Shyamal Wahie
- Department of Dermatology, County Durham and Darlington NHS Foundation Trust
- Keith Armstrong
- Department of Dermatology, Royal Victoria Hospital
- Nicola Cooke
- Department of Dermatology, Whiteabbey Hospital, Northern Health & Social Care Trust
- Mark Goodfield
- Department of Dermatology, Chapel Allerton Hospital, Leeds teaching Hospitals NHS Trust
- Irene Man
- Department of Dermatology, Surrey and Sussex Healthcare NHS Trust
- David de Berker
- Department of Dermatology, University Hospitals Bristol NHS Foundation Trust
- Giles Dunnill
- Department of Dermatology, University Hospitals Bristol NHS Foundation Trust
- Anita Takwale
- Department of Dermatology, Gloucestershire Hospitals NHS Foundation Trust
- Archana Rao
- Department of Dermatology, Kingston Hospital NHS Foundation Trust
- Tee-Wei Siah
- Department of Dermatology, Royal Victoria Infirmary
- Rodney Sinclair
- Department of Dermatology, University of Melbourne
- Martin S. Wade
- The London Skin and Hair Clinic
- Ncoza C. Dlova
- Department of Dermatology, School of Clinical Medicine, Nelson R Mandela School of Medicine
- Jane Setterfield
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Fiona Lewis
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Kapil Bhargava
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Niall Kirkpatrick
- Craniofacial Surgery Unit, Chelsea & Westminster Hospital
- Xavier Estivill
- Genetics Unit, Dexeus Women’s Health
- Catherine M. Stefanato
- Department of Dermatopathology, St. John’s Institute of Dermatology, St. Thomas’ Hospital
- Carsten Flohr
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Timothy Spector
- The Department of Twin Research & Genetic Epidemiology, King’s College London
- Fiona M. Watt
- Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital
- Catherine H. Smith
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Jonathan N. Barker
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- David A. Fenton
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- Michael A. Simpson
- Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital
- John A. McGrath
- St. John’s Institute of Dermatology, King’s College London, London, Guy’s Hospital
- DOI
- https://doi.org/10.1038/s41467-019-09117-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation which highlights HLA-B*07:02 as a risk factor.
