Nature Communications (May 2020)
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
- Arnaud Blomme,
- Catriona A. Ford,
- Ernest Mui,
- Rachana Patel,
- Chara Ntala,
- Lauren E. Jamieson,
- Mélanie Planque,
- Grace H. McGregor,
- Paul Peixoto,
- Eric Hervouet,
- Colin Nixon,
- Mark Salji,
- Luke Gaughan,
- Elke Markert,
- Peter Repiscak,
- David Sumpton,
- Giovanny Rodriguez Blanco,
- Sergio Lilla,
- Jurre J. Kamphorst,
- Duncan Graham,
- Karen Faulds,
- Gillian M. MacKay,
- Sarah-Maria Fendt,
- Sara Zanivan,
- Hing Y. Leung
Affiliations
- Arnaud Blomme
- CRUK Beatson Institute, Garscube Estate
- Catriona A. Ford
- CRUK Beatson Institute, Garscube Estate
- Ernest Mui
- Institute of Cancer Sciences, University of Glasgow, Garscube Estate
- Rachana Patel
- CRUK Beatson Institute, Garscube Estate
- Chara Ntala
- CRUK Beatson Institute, Garscube Estate
- Lauren E. Jamieson
- Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde
- Mélanie Planque
- Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology
- Grace H. McGregor
- CRUK Beatson Institute, Garscube Estate
- Paul Peixoto
- Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique
- Eric Hervouet
- Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique
- Colin Nixon
- CRUK Beatson Institute, Garscube Estate
- Mark Salji
- Institute of Cancer Sciences, University of Glasgow, Garscube Estate
- Luke Gaughan
- Northern Institute for Cancer Research, The Medical School, Newcastle University
- Elke Markert
- Institute of Cancer Sciences, University of Glasgow, Garscube Estate
- Peter Repiscak
- CRUK Beatson Institute, Garscube Estate
- David Sumpton
- CRUK Beatson Institute, Garscube Estate
- Giovanny Rodriguez Blanco
- CRUK Beatson Institute, Garscube Estate
- Sergio Lilla
- CRUK Beatson Institute, Garscube Estate
- Jurre J. Kamphorst
- CRUK Beatson Institute, Garscube Estate
- Duncan Graham
- Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde
- Karen Faulds
- Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde
- Gillian M. MacKay
- CRUK Beatson Institute, Garscube Estate
- Sarah-Maria Fendt
- Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology
- Sara Zanivan
- CRUK Beatson Institute, Garscube Estate
- Hing Y. Leung
- CRUK Beatson Institute, Garscube Estate
- DOI
- https://doi.org/10.1038/s41467-020-16126-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring of glucose and lipid metabolism, and further identify a signature associated with resistance to AR inhibition.
